Preheat oven to 450° F. Line a baking sheet with parchment or nonstick foil then place the salmon on skin side down. Use paper towels to pat the salmon dry.
In a small bowl, mix chili powder, cumin, garlic powder, onion powder, salt and pepper. Pour olive oil on salmon and brush to evenly coat. Pour seasoning over top of salmon. Rub the seasoning all over the top of the filets.
Place in oven and cook until center reaches 145° F or until it easily flakes with a fork. Should take 10-20 minutes depending on thickness.
While salmon is baking, make salsa by adding avocado, mango, tomatoes, jalapeno, red onion, lime juice and Tajin in a large bowl and toss to combine.
Heat tortillas on a griddle or in a skillet over medium-high heat.
Once salmon is done, remove from oven and flake into large pieces using a knife or fork. Place in warmed tortillas and top with avocado mango salsa.